What is Evamist®?
Evamist (estradiol transdermal spray) is the only low-dose estrogen spray hormone therapy product approved in the US. Find out more about Evamist.1
What is Evamist for?
Evamist is indicated for the treatment of moderate-to-severe hot flashes due to menopause. Find out more about Evamist.1
How do I take Evamist?
Your doctor will prescribe the dosage of Evamist that’s right for you. It may be one, two, or three sprays per day to the inner forearm. Find out more about Evamist.1
What do I do if I miss a dose?
If you miss a dose, do not double up on the dose the next day in an attempt to catch up. If the next dose is less than 12 hours away, it is best to wait and apply the normal dose the next day. If the next dose is more than 12 hours away, it is acceptable to apply the missed dose and resume normal dosing the next day. Find out more about Evamist.1
How do I apply Evamist?
Evamist is applied with an applicator that controls the distance, angle, and area of application of the spray. It is designed to give the right amount of medication with each spray, minimizing the risk of inappropriate application. Before the first use, prime the pump by spraying three times into the cover. The pump should be held upright and vertical for spraying. Then, press the applicator cone against the inner forearm and fully depress the pump. If more than one spray per dose is prescribed, move the cone to an area of the skin next to but not touching the area of the previous spray before applying the second or third spray. Do not apply Evamist to other areas of the skin. Never apply Evamist directly to the breast or in or around the vagina. Click here for complete dosing instructions.1
What are the side effects of Evamist?
Evamist is generally well-tolerated. The most common side effects that may occur with Evamist are headache, breast tenderness, the common cold, nipple pain, back pain, nausea, and joint pain.1
Estrogens increase the chance of getting cancer of the uterus (womb). Report any unusual vaginal bleeding right away while you are using Evamist. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus. Your healthcare provider should check any unusual vaginal bleeding to find out the cause.1
Do not use estrogens with or without progestins to prevent heart disease, heart attacks, strokes, or dementia. Using estrogens, with or without progestins, may increase your chance of getting heart attacks, strokes, breast cancer, and blood clots. Using estrogen, with or without progestins, may increase your risk of dementia, based on a study of women age 65 years or older. Evamist should not be used if you have unusual vaginal bleeding; currently have or have had certain cancers, including cancer of the breast or uterus; had a stroke or heart attack in the past year; currently have or have had blood clots; currently have or have had liver problems; or think you may be, or know that you are, pregnant.1 Read the complete prescribing information here.
Who should not take Evamist?
Evamist should not be used if you have unusual vaginal bleeding; currently have or have had certain cancers, including cancer of the breast or uterus; had a stroke or heart attack in the past year; currently have or have had blood clots; currently have or have had liver problems; or think you may be, or know that you are, pregnant. Find out more about Evamist.1
How long does Evamist take to dry?
Evamist dries in a median of 67 seconds. To prevent getting medicine on your clothing, allow Evamist to dry at least 2 minutes before dressing, and at least 30 minutes before washing. Find out more about taking Evamist.1,2
Is it possible to transfer the drug to others if they touch the application site?
To prevent transfer to another person, don’t allow others to make contact with the area of skin where Evamist was applied for at least 30 minutes after application. Find out more about taking Evamist.1
How long after Evamist is applied should I wait before bathing?
After applying Evamist, you should wait at least 30 minutes before washing the area. Find out more about taking Evamist.1
Does sunscreen affect Evamist?
No specific recommendation has been made with respect to sunscreen use before or after application of Evamist. However, it’s possible that when sunscreen is applied approximately one hour after application of Evamist, absorption is affected, whereas absorption is unaffected when applied approximately one hour before application of Evamist. Find out more about taking Evamist.1
Can Evamist be applied to skin that might be irritated or cut?
No, Evamist should be applied to clean, dry, unbroken skin. If you have a cut or irritated skin on the forearm, use the other forearm or another area of the forearm as the application site. Find out more about taking Evamist.1
Does Evamist have to be applied to the same arm each day?
Evamist does not need to be applied to the same inner forearm each day. Find out more about taking Evamist.1
Will Evamist irritate my skin?
Evamist has a very low risk of skin irritation. Find out more about taking Evamist.2
If I am currently taking another hormone therapy, how should I transition to Evamist?
There is no standard dosing regimen for switching from another hormone therapy to Evamist. Your doctor will likely start you out with one spray per day. Dose adjustments will be guided by how well your hot flashes are controlled. Based on your symptom relief, your doctor can decide whether two or three sprays per day is needed. Find out more about Evamist.1
» References
Important Safety Information
Evamist® is approved by the FDA for use after menopause to reduce moderate-to-severe hot flashes.

Estrogens increase the chance of getting cancer of the uterus (womb). Report any unusual vaginal bleeding right away while you are using Evamist. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus. Your healthcare provider should check any unusual vaginal bleeding to find out the cause.

Do not use estrogens with or without progestins to prevent heart disease, heart attacks, strokes, or dementia. Using estrogens, with or without progestins, may increase your chance of getting heart attacks, strokes, breast cancer, and blood clots. Using estrogen, with or without progestins, may increase your risk of dementia, based on a study of women age 65 years or older. Evamist should not be used if you have unusual vaginal bleeding; currently have or have had certain cancers, including cancer of the breast or uterus; had a stroke or heart attack in the past year; currently have or have had blood clots; currently have or have had liver problems; or think you may be, or know that you are, pregnant.

The most common side effects that may occur with Evamist are headache, breast tenderness, the common cold, nipple pain, back pain, nausea, and joint pain.

You and your healthcare provider should talk regularly about whether you still need treatment with Evamist.

Please see full prescribing information for Evamist.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

 
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